CELLULAR DIFFERENTIATION AND THE AGING PROCESS IN CARTILAGINOUS TISSUES
نویسندگان
چکیده
منابع مشابه
Cellular Differentiation and the Aging Process in Cartilaginous Tissues
Primary cell cultures of differentiated chondrocytes were shown to produce chondroitin-4-sulfate as the predominant mucopolysaccharide, with suggestive evidence for the synthesis of keratan sulfate and possibly chondroitin-6-sulfate. Chicken embryonic cartilage was shown to be composed mainly of chondroitin-4-sulfate, with a small amount of chondroitin-6-sulfate, but essentially no keratan sulf...
متن کاملCellular networks and the aging process.
The most important interactions between cellular molecules have a high affinity, are unique and specific, and require a network approach for a detailed description. After a brief introduction to cellular networks (protein--protein interaction networks, metabolic networks, gene regulatory networks, signalling networks and membrane--organelle networks) an overview is given on the network aspects ...
متن کاملMixed finite element modelling of cartilaginous tissues
Swelling and shrinking of cartilaginous tissues is modelled by a four-component mixture theory. This theory results in a set of coupled non-linear partial differential equations for the electro-chemical potentials and the displacement. For the sake of local mass conservation these equations are discretised in space by a mixed finite element method. Integration in time by backward Euler leads to...
متن کاملReprogramming development and aging: cell differentiation as a malleable process.
Juan Carlos Izpisua Belmonte received his PhD from the University of Bologna, Italy and the University of Valencia, Spain in 1987. After postdoctoral stages at the EMBL in Heidelberg, Germany, and UCLA, Los Angeles, USA, in 1993 he moved to the Salk Institute for Biological Studies in La Jolla, California where he is currently a professor in the Gene Expression Laboratories. Since 2005 he is al...
متن کاملDetection of Cellular Aging in a Galton-watson Process
We consider the bifurcating Markov chain model introduced by Guyon to detect cellular aging from cell lineage. To take into account the possibility for a cell to die, we use an underlying Galton-Watson process to describe the evolution of the cell lineage. We give in this more general framework a weak law of large number, an invariance principle and thus fluctuation results for the average over...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1968
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.128.6.1353